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The interest of scientists, physicians, pediatricians, general practitioners to the problem of intestinal dysbiosis is caused by the fact that there are very close relations between the intestinal microbiocenosis disorders and organic and functional pathology not only of the gastrointestinal tract, but also of other organs. For more than 50 years probiotics have been the leading tool for correction of intestinal microbiocenosis. However, the response of intestinal microbiota to exogenous intake of probiotics is variable, or is completely absent. The article presents the analysis of the literature data and results of our own experimental studies on human volunteers, fully confirming previous findings on laboratory animals, according to which the probiotic microorganisms are foreign and do not survive in the gastrointestinal tract of humans and animals, and their interaction with the host organism has the character of «host against probiotic». The results of the comparative study on the effectiveness of 18 modern preparations for correction of intestinal microbiocenosis at antibiotic-associated dysbiosis in experiments on animals are given. The comparative experimental research on the effectiveness of modern preparations that are frequently used in clinical practice as well as recent innovative commercial and experimental preparations (Actoflor-C. Stimbifid plus, Stimex) regarding intestinal microbiota recovery at antibioticassociated dysbiosis in conventional white mice was carried out.

About the Authors

I. Yu. Chicherin
Scientific society «Microbiota»
Russian Federation

Igor Yu. Chicherin — candidate of medical sciences President.

Pos. Loza, 9-D, Sergiev Posadsky district, Moscow region., 141323, tel.: +7-496-547-53-00

I. P. Pogorelsky
Vyatka State University
Russian Federation

Ivan P. Pogorelsky — doctor of medical sciences, professor, professor of the Department of Microbiology.

Moskovskaya st., 36, Kirov, 610000, tel.: +7-8332-74-24-40

I. A. Lundovskikh
Vyatka State University
Russian Federation

Irina A. Lundovskikh — candidate of chemical sciences, docent, docentof the Department of Microbiology, Institute of Biology and Biotechnology.

Moskovskayast., 36, Kirov, 610000, tel.: +7-8332-74-24-40

I. V. Darmov
Vyatka State University
Russian Federation

Ilya V. Darmov — doctor of medical sciences, Professor, Head of the Department of Microbiology, Institute of Biology and Biotechnology.

Moskovskayast., 36, Kirov, 610000, tel.: +7-8332-74-24-40

M. R. Shabalina
Vyatka State University
Russian Federation

Marina R. Shabalina — candidate of pedagogical sciences,docent, docentof the Department of Fundamental and applied Mathematics, Institute of Mathematics and Information Systems.

Moskovskaya st., 36, Kirov,  610000, tel.: +7-8332-74-25-15


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For citation:

Chicherin I.Yu., Pogorelsky I.P., Lundovskikh I.A., Darmov I.V., Shabalina M.R. INTESTINAL DYSBIOSIS, HUMAN HEALTH AND FUNCTIONAL NUTRITION. Theory and practice of meat processing. 2017;2(4):44-61. (In Russ.)

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