The therapeutic role of the alcoholic extract of Gundelia tourneofortti l. in Salmonella typhimurium infection and its health effects in laboratory rats
https://doi.org/10.21323/2414-438X-2025-10-2-147-155
Abstract
This study investigates the effectiveness of the alcoholic extract of Gundelia tournefortii L. in mitigating the effects of Salmonella Typhimurium infection on hematological parameters and liver and kidney function in laboratory animals. S. Typhimurium was isolated from 23 samples of food and stool collected from pediatric patients (aged 1–6 years) with diarrhea at Salah al-Din Hospital. The findings indicate that infection with S. Typhimurium led to a significant increase (P < 0.05) in total white blood cell (WBC) and platelet counts, reaching 28.16 × 10³/µL and 713 × 10³/µL, respectively, compared to the control values of 8.50 × 10³/µL and 658 × 10³/µL. Conversely, red blood cell (RBC) and hemoglobin (Hb) levels were significantly reduced (P < 0.05) in infected animals, measuring 5.79 × 10⁶/µL and 13.0 g/dL, respectively, compared to 4.60 × 10⁶/µL and 14.10 g/dL in the control group. Liver function tests revealed elevated levels of alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in infected rats, with values of 164.0, 142.0, and 66.0 IU/L, respectively, compared to the control values. Renal function analysis showed a significant increase (P < 0.05) in urea concentration in the infected group (48.5 mg/dL) relative to the controls (41.2 mg/dL), while no significant differences were observed in creatinine levels between groups. Notably, administration of the alcoholic extract at doses of 200 and 400 µg/kg significantly mitigated the adverse effects of infection, demonstrating its potential therapeutic efficacy.
About the Authors
Ya. I. Al-Hadidy
https://www.meatjournal.ru/jour
Tikrit University
Iraq
Tikrit University
Iraq
Yasmeen I. Al-Hadidy, hD, Associate Professor
College of Agriculture; Department of Food Sciences
34001;Tikrit
Tel.: +964–770–516–62–97
Gh. H. Abdulkreem
https://www.meatjournal.ru/jour
Tikrit University
Iraq
Tikrit University
Iraq
Ghenaa H. Abdulkreem, PhD, Lecturer
College of Agriculture; Department of Food Sciences
34001; Tikrit
Tel.: +964–770–516–62–97
Ch. M. Werdi
https://www.meatjournal.ru/jour
University of Kirkuk
Iraq
University of Kirkuk
Iraq
Chalang M. Werdi, MSC, Assistant Lecturer
College of Veterinary Medicine; Department of Veterinary public health
36006; Taza
Tel.: +964–770–661–47–34
S. T. Hadi
https://www.meatjournal.ru/jour
University of Anbar
Iraq
University of Anbar
Iraq
Sara T. Hadi, MSC, Associate Professor
College of Agriculture; Department of Food Sciences
Ramadi; Anbar
Tel.: +964–780–214–64–20
A. B. Altemimi
https://www.meatjournal.ru/jour
University of Basrah; University of Warith Al-Anbiyaa
Iraq
University of Basrah; University of Warith Al-Anbiyaa
Iraq
Ammar B. Altemimi, Professor
College of Agriculture; Department of Food Science; College of Medicine
61004; Basrah; 56001; Karbala
Tel.: +964–773–564–00–90
T. G. Abedelmaksoud
https://www.meatjournal.ru/jour
Cairo University
Egypt
Cairo University
Egypt
Tarek G. Abedelmaksoud, Associate Professor
Faculty of Agriculture; Food Science Department
12613; 1 Gamaa Street; Giza
Tel.: +2–0110–144–12–80
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For citations:
Al-Hadidy Ya.I., Abdulkreem G.H., Werdi Ch.M., Hadi S.T., Altemimi A.B., Abedelmaksoud T.G. The therapeutic role of the alcoholic extract of Gundelia tourneofortti l. in Salmonella typhimurium infection and its health effects in laboratory rats. Theory and practice of meat processing. 2025;10(2):147-155. https://doi.org/10.21323/2414-438X-2025-10-2-147-155
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