Systemic approach in the development of functional foods for various noncommunicable diseases
https://doi.org/10.21323/2414-438X-2022-7-3-164-176
Abstract
The article presents a hierarchy of requirements necessary for the successful design of food products with given composition and properties considering age restrictions and various diseases. The need for generalization and systematization of scientifically based principles, specific medical and biological requirements for food products, diets for the most common nutritional diseases in the knowledge base is shown. Using the k-means cluster analysis method, 1) meat raw materials were analyzed for inclusion in functional food for gerodietetic nutrition according to the most significant descriptors (protein, methionine + cystine amino acids, tryptophan), 2) spicy herbs and spices were analyzed for inclusion in the Muhammara recipe as natural antioxidant sources according to the descriptor of antioxidant properties. Using the example of the Muhammara recipe change, all stages of a systemic approach in the development of functional foods are shown. The first stage is related to obtaining information from the knowledge base about scientifically based nutritional principles and specific biomedical requirements for the given age group. At the second stage, the clustering of raw materials of animal and vegetable origin is carried out in order to reasonably include in the recipe of food product being developed. At the third stage, a system of balance linear algebraic equations for the chemical composition of the food product being developed (mass fraction of fat, protein, water, carbohydrates, vitamins, macro- and microelements, amino acids, etc.) is formed. The fourth stage is associated with the establishment of the target function (optimization criterion), and restrictions for recipe and balance. At the fifth stage, the problem is solved using a high-level language in a modern programming environment. At the final (sixth) stage, the nutritional value of the optimal balanced recipe is analyzed considering the target function and the given restrictions. As a result, we receive a modified Muhammara recipe with optimized protein: fat ratio. Mathematical simulation was carried out using the R Studio software with open-source lpSolve and lpSolveAPI libraries.
About the Authors
I. M. ChernukhaRussian Federation
Irina M. Chernukha, Doctor of Technical Sciences, Professor, Academician of the Russian Academy of Sciences, Head of the Department for Coordination of Initiative and International Projects
26, Talalikhina, 109316, Moscow
Tel: +7–495–676–95–11 (109)
M. A. Nikitina
Russian Federation
Marina A. Nikitina, Doctor of Technical Sciences, Docent, Leading Scientific Worker, the Head of the Direction of Information Technologies of the Center of Economic and Analytical Research and Information Technologies
26, Talalikhina, 109316, Moscow
Tel: +7–495–676–95–11 (297)
M. A. Aslanova
Russian Federation
Marietta A. Aslanova, Candidate of Technical Sciences, Leading Research Scientist
26, Talalikhina str., 109316, Moscow
Tel: +7–495–676–95–11 (263)
A. T. Qusay
Russian Federation
Abu T. Qusay, Postgraduate Student
33, Talalikhina, 109316, Moscow
Tel: +7–499–750–01–11(6015)
References
1. Chernukha, I.M., Fedulova, L.V., Dydykin, A.S. (2014). Safe and useful products as the main factor determining the quality of life. Vsyo o Myase, 2, 20–22. (In Russian)
2. Zhang, W., Xiao, S., Samaraweera, H., Lee, E.J., Ahn, D.U. (2010). Improving functional value of meat products. Meat Science, 86(1), 15–31. https://doi.org/10.1007/s13197–015–1861–9
3. Tutelyan, V.A., Nikityuk, D.B., Buriak, D.A., Akolzina, S.E., Baturin, A.K., Pogozheva, A.V. et al. (2018). Quality of Life. Health and Nutrition: Atlas. Moscow: Meditsina [Medicine Publishing House], 2018.
4. Vorobeva, V.M., Derbeneva, S.A., Zaletova, T.S., Kotenkova, E.A., Kochetkova, A.A., Pogozheva, A.V. et al. (2021). The use of specialized food products in the diet therapy of patients with cardiovascular pathology. St. Petersburg: High-tech technologies, 2021. (In Russian)
5. WHO reveals leading causes of death and disability worldwide: 2000–2019. Retrieved from https://www.who.int/news/item/09–12–2020-who-reveals-leading-causes-of-death-and-disability-worldwide-2000–2019 Accessed June 24, 2022.
6. The Demographic Yearbook of Russia. Retrieved from https://gks.ru/bgd/regl/B21_16/Main.htm Accessed June 14, 2022. (In Russian)
7. Heidenreich, P. A., Trogdon, J. G., Khavjou, O. A., Butler, J., Dracup, K., Ezekowitz, M. D., et al. (2011). Forecasting the future of cardiovascular disease in the United States: A policy statement from the American Heart Association. Circulation, 123(8), 933–944. https://doi.org/10.1161/CIR.0b013e31820a55f5
8. Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M. et al. (2022). 2022 AHA/ACC/HFSA guideline for the management of heart failure. Journal of Cardiac Failure, 28(5), e1-e167. https://doi.org/10.1016/j.cardfail.2022.02.010
9. Scarborough, P., Kaur, A., Cobiac, L.J. (2022). Forecast of myocardial infarction incidence, events and prevalence in England to 2035 using a microsimulation model with endogenous disease outcomes. PLoS ONE, 17 (6 June), Article e0270189. https://doi.org/10.1371/journal.pone.0270189
10. Camm, A.J., Lüscher, T.F., Maurer, G., Serruys, P.W. (2019). The ESC Textbook of Cardiovascular Medicine, Oxford University Press, 2019
11. Smetneva, N. S., Pogozheva, A. V., Vasil’ev, Y. L., Dydykin, S. S., Dydykina, I. S., Kovalenko, A. A. (2020). The role of optimal nutrition in the prevention of cardiovascular diseases. Voprosy Pitaniia, 89(3), 114–124. https://doi.org/10.24411/0042–8833–2020–10035 (In Russian)
12. Chareonrungrueangchai, K., Wongkawinwoot, K., Anothaisintawee T., Reutrakul, S. (2020). Dietary factors and risks of cardiovascular diseases: an umbrella review. Nutrients, 12(4), Article 1088. https://doi.org/10.3390/nu12041088
13. De Souza, R. J., Mente, A., Maroleanu, A., Cozma, A. I., Ha, V., Kishibe, T. et al. (2015). Intake of saturated and trans unsaturated fatty acids and risk of all-cause mortality, cardiovascular disease, and type 2 diabetes: Systematic review and meta-analysis of observational studies. BMJ (Online), 351, Article h3978. https://doi.org/10.1136/bmj.h3978
14. Pan, W.H., Lai, Y.H., Yeh, W.-T., Chen, J.-R., Jeng, J.-S., Bai, C.-H. et al. (2017). Intake of potassium-and magnesium-enriched salt improves functional outcome after stroke: a randomized, multicenter, double-blind controlled trial. The American Journal of Clinical Nutrition, 106(5), 1267–1273. https://doi.org/10.3945/ajcn.116.148536
15. Chen, Z., Glisic, M., Song, M., Aliahmad, H.A., Zhang, X., Moumdjian, A.C. et al. (2020). Dietary protein intake and all-cause and cause-specific mortality: results from the Rotterdam Study and a meta-analysis of prospective cohort studies. European Journal of Epidemiology, 35, 411–429. https://doi.org/10.1007/s10654–020–00607–6
16. Song, M., Fung, T.T., Hu, F.B., Willett, W.C., Longo, V.D., Chan, A.T. et al. (2016). Association of animal and plant protein intake with all-cause and cause-specific mortality. JAMA Internal Medicine, 176(10), 1453–1463. https://doi.org/10.1001/jamainternmed.2016.4182
17. Jayedi, A., Ghomashi, F., Zargar, M.S., Shab-Bidar, S. (2019). Dietary sodium, sodium-to-potassium ratio, and risk of stroke: a systematic review and nonlinear dose-response meta-analysis. Clinical Nutrition, 38(3), 1092–1100. https://doi.org/10.1016/j.clnu.2018.05.017
18. Fang, X., Wang, K., Han, D., He, X., Wei, J., Zhao, L. et al. (2016). Dietary magnesium intake and the risk of cardiovascular disease, type 2 diabetes, and all-cause mortality: a dose-response metaanalysis of prospective cohort studies. BMC Medicine, 14(1), Article 210. https://doi.org/10.1186/s12916–016–0742-z
19. Barbarawi, M., Kheiri, B., Zayed, Y., Barbarawi, O., Dhillon, H., Swaid, B. et al. (2019). Vitamin D supplementation and cardiovascular disease risks in more than 83 000 individuals in 21 randomized clinical trials: A meta-analysis. JAMA Cardiology, 4(8), 765–776. https://doi.org/10.1001/jamacardio.2019.1870
20. Pogozheva, A.V. (2020). The role of potassium and magnesium for prevention and treatment of cardiovascular disease. Consilium Medicum, 22(10), 76–79. https://doi.org/10.26442/20751753.2020.10.200336
21. Leser, S. (2013). The 2013 FAO report on dietary protein quality evaluation in human nutrition: Recommendations and implications. Nutrition Bulletin, 38(4), 421–428. https://doi.org/10.1111/nbu.12063
22. Abdelhamid, A.S., Brown, T.J., Brainard, J.S., Biswas, P., Thorpe, G.C., Moore, H.J. et al. (2020). Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews, 2020(3), Article CD003177. https://doi.org/10.1002/14651858.CD003177.pub5
23. Hooper, L., Khudairy, L., Abdelhamid, A.S., Rees, K., Brainard, J.S., Brown, T.J. et al. (2018). Omega-6 fats for the primary and secondary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews, 2018(7), Article CD011094. https://doi.org/10.1002/14651858.CD011094.pub4
24. Stark, K.D., Van Elswyk, M.E., Higgins, M.R., Weatherford, C.A., Salem, N. (2016). Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults. Progress in Lipid Research, 63, 132–152. https://doi.org/10.1016/j.plipres.2016.05.001
25. Mikhin, V.P., Shveynov, A.I., Kharchenko, A.V. (2017). Impact of omega-3 polyunsaturated fatty acids on arrhythmic activity of myocardium and characteristics of cardiac rhythm in patients with unstable angina. Mezhdunarodnyi Zhurnal Serdtsa i Sosudistykh Zabolevanii, 5(15), 11–16. (In Russian)
26. Threapleton, D.E., Greenwood, D.C., Evans, C.E.L., Cleghorn, C.L., Nykjaer, C., Woodhead, C. et al. (2013). Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis. BMJ (Online), 347, Article f6879. https://doi.org/10.1136/bmj.f6879
27. Zhang, Z., Xu, G., Liu, D. Zhu, W., Fan, X., Liu, X. (2013). Dietary fiber consumption and risk of stroke. European Journal of Epidemiology, 28(2), 119–130. https://doi.org/10.1007/s10654–013–9783–1
28. McRae, M.P. (2017). Dietary fiber is beneficial for the prevention of cardiovascular disease: an umbrella review of metaanalyses. Journal of Chiropractic Medicine, 16(4), 289–299. https://doi.org/10.1016/j.jcm.2017.05.005
29. United Nations. Problems of the elderly and the aged. Draft program and arrangements for the World Assembly on the Elderly: report of the Secretary — General. (2011). Retrieved from https://documents-dds-ny.un.org/doc/UNDOC/GEN/N11/466/46/PDF/N1146646.pdf? OpenElement Accessed June 15, 2022. (In Russian)
30. Pogozheva, A. V. (2021). Eat, drink, don’t get sick. The unique principles of gerodietetics and geriatrics for healthy and therapeutic nutrition in older people. Moscow: DeLi, 2021. (In Russian)
31. Puzin, S. N., Pogozheva, A. V., Potapov, V. N. (2018). Optimizing nutrition of older people as a mean of preventing premature aging. Voprosy Pitaniia, 87(4), 69–77. https://doi.org/10.24411/0042–8833–2018–10044 (In Russian)
32. Pogozheva, A. V. (2017). Principles of nutrition optimization for the elderly. Clinical Gerontology, 23(11–12), 74–83. https://doi.org/10.26347/1607–2499201711–12074–079 (In Russian)
33. Reid-McCann, R.J., Brennan, S.F., McKinley, M.C., McEvoy, C.T. (2022). The effect of animal versus plant protein on muscle mass, muscle strength, physical performance and sarcopenia in adults: protocol for a systematic review. Systematic Reviews, 11(1), Article 64. https://doi.org/10.1186/s13643–022–01951–2
34. Matison, A.P., Milte, C.M., Shaw, J.E., Magliano, D.J., Daly, R.M., Torres, S.J. (2022). Association between dietary protein intake and changes in health-related quality of life in older adults: findings from the AusDiab 12-year prospective study. BMC Geriatrics, 22(1), Article 211. https://doi.org/10.1186/s12877–022–02894-y
35. Potemkina, N. S., Krut’ko, V. N., Mamikonova, O. A. (2017). Convergence of dietological approaches to prevention of chronic diseases of elderly. Clinical Gerontology, 23(9–10), 52–53. (In Russian)
36. Pochitaeva, I.P. (2017). Proper nutrition in the elderly -prevention of risks of disease development. Clinical Gerontology, 23 (9–10), 53–54. (In Russian)
37. Hruby, A., Sahni, S., Bolster, D., Jacques P. F. (2020). Protein intake and functional integrity in aging: The Framingham heart study offspring. Journals of Gerontology — Series A Biological Sciences and Medical Sciences, 75(1), 123–130. https://doi.org/10.1093/gerona/gly201
38. Paul, C., Leser S., Oesser, S. (2019). Significant amounts of functional collagen peptides can be included in the diet while maintaining the required amino acid balance. Nutrients, 11(5), Article 1079. https://doi.org/10.3390/nu11051079
39. Mansour, S.R., Moustafa, M.A.A., Saad, B.M., Hamed, R., Moustafa, A.-R.A. (2021). Impact of diet on human gut microbiome and disease risk. New Microbes and New Infections, 41(5), Article 100845. https://doi.org/10.1016/j.nmni.2021.100845
40. Yu, B., Akushevich, I., Yashkin, A.P., Yashin, A.I., Lyerly, H.K., Kravchenko, J. (2022). Epidemiology of geographic disparities in heart failure among US older adults: a Medicare-based analysis. BMC Public Health, 22(1), Article 1280. https://doi.org/10.1186/s12889–022–13639–2
41. Tucci, M., Mirko, M., Martini, D., Porrini, M., Riso, P., Del Bo’, C.D. (2022). Plant-based foods and vascular function: A systematic review of dietary intervention trials in older subjects and hypothesized mechanisms of action. Nutrients, 14(13), Article 2615. https://doi.org/10.3390/nu14132615
42. Dietary protein quality evaluation in human nutrition. (2013). FAO Food and Nutrition Paper, 92, 1–66.
43. Bauer, J., Biolo, G., Cederholm, Т., Cesari, M., Cruz-Jentoft, A.J., Morley, J. E. et al. (2013). Evidence-based recommendations for optimal dietary protein intake in older people: A position paper from the prot-age Study Group. Journal of the American Medical Directors Association, 14(8), 542–559. https://doi.org/10.1016/j.jamda.2013.05.021
44. Kalinchenko, S. Yu. (2017). Diseases of civilization of the 21st century: are only genes to blame? A new model of medicine: 5p medicine as medicine of effective prophylaxis and therapy. Nutrition, 7(1), 5–9. https://doi.org/10.20953/2224–5448–2017–1–5–9 (In Russian)
45. EFSA (2017). Dietary reference values for nutrients. Summary report. EFSA Supporting Publications, 14(12), Article e15121E. https://doi.org/10.2903/sp.efsa.2017.e15121
46. Vorslov, L.O. (2017). Omega-3-polyunsaturated fatty acids as a source of longevity. Nutrition, 7(1), 36–41. https://doi.org/10.20953/2224–5448–2017–1–36–41 (In Russian)
47. Zhukov, A. Yu., Vorslov, L.O., Davidyan, O.V. (2017). Omega-3 index: a modern insight and place in clinical practice. Nutrition, 7(2), 69–74. https://doi.org/10.20953/2224–5448–2017–2–69–74 (In Russian)
48. Kochetkova, A.A., Kodentsova, V.M., Besonov, V.V., Mazo, V.K., Sarkisyan, V.A., Glszkova, I.V. et al. (2016). Lipid modules in specialized foods and diets. Moscow: Biblio-Globus, 2016. https://doi.org/10.18334/9785990927803 (In Russian)
49. Van Den Brink, A.C., Brouwer-Brolsma, E.M., Berendsen, A.A.M., Van De Rest, O. (2019). The Mediterranean, dietary approaches to stop hypertension (DASH), and Mediterranean-DASH intervention for neurodegenerative delay (MIND) diets are associated with less cognitive decline and a lower risk of Alzheimer’s disease — A Review. Advances in Nutrition, 10(6), 1040–1065. https://doi.org/10.1093/advances/nmz054
50. Song, X., Giacalone, D., Johansen, S.M.B., Frøst, M.B., Bredie, W.L.P. (2016). Changes in orosensory perception related to aging and strategies for counteracting its influence on food preferences among older adults. Trends in Food Science and Technology, 53, 49–59. https://doi.org/10.1016/j.tifs.2016.04.004
51. Govindaraju, T., Sahle, B.W., McCaffrey, T.A., McNeil, J.J., Owen, A.J. (2018). Dietary patterns and quality of life in older adults: A systematic review. Nutrients, 10(8), Article 971. https://doi.org/10.3390/nu10080971
52. Browning, C.J., Qiu, Z., Yang, H., Zhang, T., Thomas, S.A. (2019). Food, eating, and happy aging: The perceptions of older Chinese people. Frontiers in Public Health, 7(APR), Article 73. https://doi.org/10.3389/fpubh.2019.00073
53. Nikitina, M.A., Lisitsyn, A.B., Zakharov, A.N., Sus, EB., Pilugina, S.A., Dydykin, A.S. et al. Food products. Certificate of registration of the database RF no. 2015620557. 2015.(In Russian)
54. Nikitina, M.A., Chernukha, I.M., Uzakov, Y.M., Nurmukhanbetova, D.E. (2021). Cluster analysis for databases typologization characteristics. News of the National Academy of Sciences of the Republic of Kazakhstan, Series of Geology and Technical Sciences, 2(446), 114–121. https://doi.org/10.32014/2021.2518–170X.42
55. Crolemund, G., Wickham, H. (2017). R for Data Science: Import, Tidy, Transform, Visualize, and Model Data. Beijing, Boston, Farnham, Sebastopol, Tokyo: O’Reilly Media, 2017.
56. Matloff, N. (2011). The Art of R Programming: А Tour of Statistical Software Design. San Francisco: William Pollock. 2011.
57. Lisitsyn, A.B., Chernukha, I.M., Fedulova, L. V. Kotenkova, E. A. Functional meat product and method of its production. Patent RF, no. 2550649, 2015. (In Russian)
58. Chernukha, I., Kotenkova, E., Derbeneva, S., Khvostov, D. (2021). Bioactive compounds of porcine hearts and aortas may improve cardiovascular disorders in humans. International Journal of Environmental Research and Public Health, 18(14), Article 7330. https://doi.org/10.3390/ijerph18147330
59. Brunel, M., Chernukha, I.M., Kotenkova, E.A., Fedulova, L.V., Moazzami, A.A., Sampels, S. et al. (2020). Possibility to use porcine aorta and heart tissue-based product in a diet of patients with metabolic diseases. Collection of papers XIV International Biotechnological Forum “Rosbiotech-2020”, 147–152.
60. Chernukha, I., Kotenkova, E. (2020). A randomised controlled trial of innovative specialised meat product for patients with cardiovascular and metabolic disorders. Potravinarstvo Slovak Journal of Food Sciences, 14(1), 458–464. https://doi.org/10.5219/1298
61. Kantorovich, L.V. (1939). Mathematical methods of production organization and planning. Leningrad: Leningrad State University Publishing House, 1939. (In Russian)
62. Kantorovich, L.V. (1959). Economic calculation of the resource optimal usage. Moscow: House of the USSR Academy of Sciences, 1959. (In Russian)
63. Dantzig, G.B. (1956). Linear Inequalities and Related Systems. Princeton: Princeton University Press. 1956.
64. Dantzig, G.B. (1963). Linear Programming and Extensions. Princeton: Princeton University Press, 1963.
65. Gladkikh, N.M., Fedulova, L.V. (2017). Biological value of canned minced meat specialized. Vsyo o Myase, 3, 28–31. (In Russian)
66. Yudina, S.B. (2018). Functional food technology. Saint-Petersburg: Lan, 2018.
67. Aslanova, M.A., Dydykin, A.S., Lisitsyn, A.B., Derevitskaya, O.K. (2020). Functional meat products of gerodietetic direction. Collection of papers XIV international biotechnological forum “Rosbiotech-2020”, 100–103. (In Russian)
68. Sergeev, V.N., Apkhanova, T.V., Dydykin, A.S., Aslanova, M.A., Nikiforova, T.I., Tarasov A. V. et al. (2020). The use of functional meat products in diseases of the musculoskeletal system. Journal of New Medical Technologies, Edition 4, 35–43. https://doi.org/10.24411/2075–4094–2020–16683 (In Russian)
Review
For citations:
Chernukha I.M., Nikitina M.A., Aslanova M.A., Qusay A.T. Systemic approach in the development of functional foods for various noncommunicable diseases. Theory and practice of meat processing. 2022;7(3):164-176. https://doi.org/10.21323/2414-438X-2022-7-3-164-176