meatTheory and practice of meat processingТеория и практика переработки мяса2414-438X2414-441XФГБНУ «Федеральный научный центр пищевых систем им. В.М. Горбатова» РАН10.21323/2414-438X-2026-11-1-87-96meat-556Research ArticleСтатьиEconomic losses due to reproductive disorders during foot and mouth disease outbreak in Jember Regency, IndonesiaEconomic losses due to reproductive disorders during foot and mouth disease outbreak in Jember Regency, Indonesiahttps://orcid.org/0009-0000-1383-1688NugrohoR.NugrohoR.

Rifki Nugroho, M. Vet., Veterinary Practitioner, Animal Health Center of Bangsalsari

Jl. Balung, Ramguta, Bangsalsari, Bangsalsari, Jember 68154, East Java, Indonesia

Rifki Nugroho, M. Vet., Veterinary Practitioner, Animal Health Center of Bangsalsari

Jl. Balung, Ramguta, Bangsalsari, Bangsalsari, Jember 68154, East Java, Indonesia

rifnugroho@gmail.comhttps://orcid.org/0000-0003-4543-1659MustofaI.MustofaI.

Imam Mustofa, Prof, Professor, Division of Veterinary Reproduction, Faculty of Veterinary Medicine

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

Imam Mustofa, Prof, Professor, Division of Veterinary Reproduction, Faculty of Veterinary Medicine

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

imam.mustofa@fkh.unair.ac.idhttps://orcid.org/0000-0001-7110-0939LuqmanE. М.LuqmanE. M.

Epy Muhammad Luqman, Prof, Professor, Division of Veterinary Anatomy, Faculty of Veterinary Medicine

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

Epy Muhammad Luqman, Prof, Professor, Division of Veterinary Anatomy, Faculty of Veterinary Medicine

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

m-l@fkh.unair.ac.idhttps://orcid.org/0000-0001-9421-9342KhairullahA. R.KhairullahA. R.

Aswin Rafif Khairullah, PhD, Researcher 

Jl. Raya Bogor Km. 46 Cibinong, Bogor 16911, West Java, Indonesia

Aswin Rafif Khairullah, PhD, Researcher 

Jl. Raya Bogor Km. 46 Cibinong, Bogor 16911, West Java, Indonesia

aswinrafif@gmail.comhttps://orcid.org/0000-0002-1734-178XHidanahS.HidanahS.

Sri Hidanah, Prof, Professor, Division of Animal Husbandry, Faculty of Veterinary Medicine

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

Sri Hidanah, Prof, Professor, Division of Animal Husbandry, Faculty of Veterinary Medicine

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

sri-h@fkh.unair.ac.idhttps://orcid.org/0000-0002-0319-7211LokapirnasariW. P.LokapirnasariW. P.

Widya Paramita Lokapirnasari, Prof, Professor, Division of Animal Husbandry, Faculty of Veterinary Medicine 

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

Widya Paramita Lokapirnasari, Prof, Professor, Division of Animal Husbandry, Faculty of Veterinary Medicine 

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

widya-p-l@fkh.unair.ac.idhttps://orcid.org/0000-0002-2366-5027SuprayogiT. M.SuprayogiT. M.

Tri Wahyu Suprayogi, Prof, Professor, Division of Veterinary Reproduction, Faculty of Veterinary Medicine

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

Tri Wahyu Suprayogi, Prof, Professor, Division of Veterinary Reproduction, Faculty of Veterinary Medicine

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

tri-w-s@fkh.unair.ac.idhttps://orcid.org/0000-0003-3068-8718PratamaB. P.PratamaB. P.

Bima Putra Pratama, PhD, Researcher 

Jl. Raya Puspiptek 60, Setu, South Tangerang, Banten, Indonesia

Bima Putra Pratama, PhD, Researcher 

Jl. Raya Puspiptek 60, Setu, South Tangerang, Banten, Indonesia

bimaputra.pratama@gmail.comhttps://orcid.org/0000-0002-2067-717XAhmadR. Z.AhmadR. Z.

Riza Zainuddin Ahmad, PhD, Researcher 

Jl. Raya Bogor Km. 46 Cibinong, Bogor 16911, West Java, Indonesia

Riza Zainuddin Ahmad, PhD, Researcher 

Jl. Raya Bogor Km. 46 Cibinong, Bogor 16911, West Java, Indonesia

riza011@brin.go.idhttps://orcid.org/0000-0001-9443-2901HandayaniU. F.HandayaniU. F.

Ulvi Fitri Handayani, PhD, Researcher 

Jl. Raya Bogor Km. 46 Cibinong, Bogor 16911, West Java, Indonesia

Ulvi Fitri Handayani, PhD, Researcher 

Jl. Raya Bogor Km. 46 Cibinong, Bogor 16911, West Java, Indonesia

ulvi003@brin.go.idhttps://orcid.org/0000-0002-6013-0902AkintundeA. D.

Adeyinka Oye Akintunde, PhD, Assistant Professor, Department of Agriculture and Industrial Technology 

Ilishan-Remo 121103, Nigeria

adeyinka.akintunde@gmail.comhttps://orcid.org/0009-0004-5867-4646YuriA. J. B.YuriA. J. B.

Angel Jelita Brilliant Yuri, drh., Veterinary Practitioner, Profession Program of Veterinary Medicine, Faculty of Veterinary Medicine 

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

Angel Jelita Brilliant Yuri, drh., Veterinary Practitioner, Profession Program of Veterinary Medicine, Faculty of Veterinary Medicine 

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesia

angeljbyuri@gmail.comhttps://orcid.org/0009-0003-1401-9749UtomoD. L. H.UtomoD. L. H.

Desi Lailatul Hidayah Utomo, drh., Veterinary Practitioner, Profession Program of Veterinary Medicine, Faculty of Veterinary MedicineJl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesi

 

Desi Lailatul Hidayah Utomo, drh., Veterinary Practitioner, Profession Program of Veterinary Medicine, Faculty of Veterinary Medicine

Jl. Dr. Ir. H. Soekarno, Kampus C Mulyorejo, Surabaya 60115, East Java, Indonesi

Desilailatul361@gmail.comhttps://orcid.org/0000-0002-1279-3904AnsoriA. N. M.AnsoriA. N. M.

Arif Nur Muhammad Ansori, PhD, Assistant Professor, Postgraduate School, Universitas Airlangga, Kampus B Dharmawangsa; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University,, India; Medical Biotechnology Research Group, Virtual Research Center for Bioinformatics and Biotechnology

Jl. Airlangga 4–6, Surabaya, East Java 60286, Indonesia; Chakrata Rd, Dehradun, Uttarakhand 248007, India; Jl. Gunung Anyar Kidul No. 33, Surabaya, East Java 60493, Indonesia.

Arif Nur Muhammad Ansori, PhD, Assistant Professor, Postgraduate School, Universitas Airlangga, Kampus B Dharmawangsa; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University,, India; Medical Biotechnology Research Group, Virtual Research Center for Bioinformatics and Biotechnology

Jl. Airlangga 4–6, Surabaya, East Java 60286, Indonesia; Chakrata Rd, Dehradun, Uttarakhand 248007, India; Jl. Gunung Anyar Kidul No. 33, Surabaya, East Java 60493, Indonesia.

ansori.anm@gmail.comAnimal Health Center of BangsalsariИндонезияAnimal Health Center of BangsalsariIndonesiaUniversitas AirlanggaИндонезияUniversitas AirlanggaIndonesiaResearch Center for Veterinary Science, National Research and InnovationИндонезияResearch Center for Veterinary Science, National Research and InnovationIndonesiaResearch Center for Process Technology, National Research and Innovation Agency IndonesiaИндонезияResearch Center for Process Technology, National Research and Innovation AgencyIndonesiaResearch Center for Veterinary Science, National Research and Innovation AgencyИндонезияResearch Center for Veterinary Science, National Research and Innovation AgencyIndonesiaResearch Center for Animal Husbandry, National Research and Innovation AgencyИндонезияResearch Center for Animal Husbandry, National Research and Innovation AgencyIndonesiaBabcock UniversityНигерияBabcock UniversityNigeriaUniversitas Airlangga; Uttaranchal University; Virtual Research Center for Bioinformatics and BiotechnologyИндонезияUniversitas Airlangga; Uttaranchal University; Virtual Research Center for Bioinformatics and BiotechnologyIndonesia2026040420261118796Copyright © Nugroho R., Mustofa I., Luqman E.M., Khairullah A.R., Hidanah S., Lokapirnasari W.P., Suprayogi T.M., Pratama B.P., Ahmad R.Z., Handayani U.F., Akintunde A.D., Yuri A.J., Utomo D.L., Ansori A.N., 20262026Nugroho R., Mustofa I., Luqman E.М., Khairullah A.R., Hidanah S., Lokapirnasari W.P., Suprayogi T.M., Pratama B.P., Ahmad R.Z., Handayani U.F., Akintunde A.D., Yuri A.J., Utomo D.L., Ansori A.N.Nugroho R., Mustofa I., Luqman E.M., Khairullah A.R., Hidanah S., Lokapirnasari W.P., Suprayogi T.M., Pratama B.P., Ahmad R.Z., Handayani U.F., Akintunde A.D., Yuri A.J., Utomo D.L., Ansori A.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.meatjournal.ru/jour/article/view/556

Jember Regency as one of the regencies with the largest beef cattle population in East Java, recorded a high number of FMD cases. In the beef cattle farming business, reproduction is a key factor in the success of beef cattle breeding, therefore this study aims to determine how much impact FMD has on abnormalities in the cattle reproductive system so that it can be known what reproductive disorders occur, the factors that most influence abortion during FMD and the potential economic losses for farmers and business actors engaged in this field in Jember Regency. This study is a quantitative descriptive study aimed at determining the incidence of post-FMD reproductive disorders, identifying the main factors influencing abortion, and estimating the economic losses resulting from abortion and reproductive disorders based on the increase in days open and calving intervals. The results of the study showed that reproductive disorders after FMD were found in 56 % of studied animals with the largest percentage being ovarian hypofunction at 27 %. The incidence of abortion during FMD outbreaks reached 12 % and the most influential factor in the incidence of abortion was FMD virus infection. The economic losses caused by abortions were estimated at IDR 210,840,000 (approximately USD14,000), while the losses due to reproductive disorders calculated on the basis of increased days open and calving intervals were estimated at IDR 1,015,200,000 (approximately USD67,700). Based on the results of this study, it is necessary to further study service per conception, conception rate and calving rate so that the value of the livestock’s reproductive efficiency is known more precisely.

Jember Regency as one of the regencies with the largest beef cattle population in East Java, recorded a high number of FMD cases. In the beef cattle farming business, reproduction is a key factor in the success of beef cattle breeding, therefore this study aims to determine how much impact FMD has on abnormalities in the cattle reproductive system so that it can be known what reproductive disorders occur, the factors that most influence abortion during FMD and the potential economic losses for farmers and business actors engaged in this field in Jember Regency. This study is a quantitative descriptive study aimed at determining the incidence of post-FMD reproductive disorders, identifying the main factors influencing abortion, and estimating the economic losses resulting from abortion and reproductive disorders based on the increase in days open and calving intervals. The results of the study showed that reproductive disorders after FMD were found in 56 % of studied animals with the largest percentage being ovarian hypofunction at 27 %. The incidence of abortion during FMD outbreaks reached 12 % and the most influential factor in the incidence of abortion was FMD virus infection. The economic losses caused by abortions were estimated at IDR 210,840,000 (approximately USD14,000), while the losses due to reproductive disorders calculated on the basis of increased days open and calving intervals were estimated at IDR 1,015,200,000 (approximately USD67,700). Based on the results of this study, it is necessary to further study service per conception, conception rate and calving rate so that the value of the livestock’s reproductive efficiency is known more precisely.

FMDreproductive disordersabortioneconomic lossescattlediseaseFMDreproductive disordersabortioneconomic lossescattlediseaseThis study is supported by Skema Penelitian Dasar Unggulan (PDU) Universitas Airlangga Year 2023, with grant number: 1286/UN3.1.6/PT/2023.This study is supported by Skema Penelitian Dasar Unggulan (PDU) Universitas Airlangga Year 2023, with grant number: 1286/UN3.1.6/PT/2023.ReferencesKhairullah, A. R., Kurniawan, S. C., Effendi, M. H., Silaen, O. S. M., Moses, I. B., Hasib, A. et al. (2024). The danger of foot and mouth disease in livestock — A review. Borneo Journal of Resource Science and Technology, 14(2), 173–187. https://doi.org/10.33736/bjrst.5979.2024Khairullah, A. R., Kurniawan, S. C., Effendi, M. H., Silaen, O. S. M., Moses, I. B., Hasib, A. et al. (2024). The danger of foot and mouth disease in livestock — A review. Borneo Journal of Resource Science and Technology, 14(2), 173–187. https://doi.org/10.33736/bjrst.5979.2024Sirajuddin, S. N., Rasyid, I., Rahim, L., Maulana, Z., Nurhapsah, N., Ashar, N. M. (2024). Eradication and management of foot and mouth disease (FMD) in cattle in Maros Regency, South Sulawesi Province, Indonesia. Revista Electronica de Veterinaria, 25(1), 95–100.Sirajuddin, S. N., Rasyid, I., Rahim, L., Maulana, Z., Nurhapsah, N., Ashar, N. M. (2024). Eradication and management of foot and mouth disease (FMD) in cattle in Maros Regency, South Sulawesi Province, Indonesia. Revista Electronica de Veterinaria, 25(1), 95–100.Knight-Jones, T. J., Rushton, J.(2013). The economic impacts of foot and mouth disease: What are they, how big are they and where do they occur? Preventive Veterinary Medicine, 112(3–4), 161–173. https://doi.org/10.1016/j.prevetmed.2013.07.013Knight-Jones, T. J., Rushton, J.(2013). The economic impacts of foot and mouth disease: What are they, how big are they and where do they occur? Preventive Veterinary Medicine, 112(3–4), 161–173. https://doi.org/10.1016/j.prevetmed.2013.07.013Ministry of Agriculture of the Republic of Indonesia. (2022). Report on the situation of the outbreak of mouth and nail disease (PMK) in Indonesia in 2022. Jakarta, Indonesia: Directorate General of Animal Husbandry and Animal Health, 2022. (In Indonesian)Ministry of Agriculture of the Republic of Indonesia. (2022). Report on the situation of the outbreak of mouth and nail disease (PMK) in Indonesia in 2022. Jakarta, Indonesia: Directorate General of Animal Husbandry and Animal Health, 2022. (In Indonesian)Directorate General of Animal Husbandry and Animal Health, Ministry of Agriculture of the Republic of Indonesia. (2022). The 2022 report on the incidence of mouth and hoof disease (FMD) through the National Animal Health Information System (iSIKHNAS). Jakarta, Indonesia: Directorate General of Animal Husbandry and Animal Health, 2022. (In Indonesian)Directorate General of Animal Husbandry and Animal Health, Ministry of Agriculture of the Republic of Indonesia. (2022). The 2022 report on the incidence of mouth and hoof disease (FMD) through the National Animal Health Information System (iSIKHNAS). Jakarta, Indonesia: Directorate General of Animal Husbandry and Animal Health, 2022. (In Indonesian)Thompson, D., Muriel, P., Russell, D., Osborne, P., Bromley, A., Rowland, M. et al. (2002). Economic costs of the foot and mouth disease outbreak in the United Kingdom in 2001. Revue Scientifique et Technique, 21(3), 675–687. https://doi.org/10.20506/rst.21.3.1353Thompson, D., Muriel, P., Russell, D., Osborne, P., Bromley, A., Rowland, M. et al. (2002). Economic costs of the foot and mouth disease outbreak in the United Kingdom in 2001. Revue Scientifique et Technique, 21(3), 675–687. https://doi.org/10.20506/rst.21.3.1353World Organisation for Animal Health (WOAH). (2021). Terrestrial animal health code: Infection with foot and mouth disease virus. Paris, France: World Organisation for Animal Health.World Organisation for Animal Health (WOAH). (2021). Terrestrial animal health code: Infection with foot and mouth disease virus. Paris, France: World Organisation for Animal Health.Diskin, M. G. Kenny, D.A. (2016). Managing the reproductive performance of beef cows. Theriogenology, 86, 379–387. https://doi.org/10.1016/j.theriogenology.2016.04.052Diskin, M. G. Kenny, D.A. (2016). Managing the reproductive performance of beef cows. Theriogenology, 86, 379–387. https://doi.org/10.1016/j.theriogenology.2016.04.052Wiltbank, M. C., Gümen, A., Sartori, R. (2002). Physiological classifi ation of anovulatory conditions in cattle. Theriogenology, 57(1), 21–52. https://doi.org/10.1016/s0093-691x(01)00656-2Wiltbank, M. C., Gümen, A., Sartori, R. (2002). Physiological classifi ation of anovulatory conditions in cattle. Theriogenology, 57(1), 21–52. https://doi.org/10.1016/s0093-691x(01)00656-2De Vries, A. (2006). Economic value of pregnancy in dairy cattle. Journal of Dairy Science, 89(10), 3876–3885. https://doi.org/10.3168/jds.s0022-0302(06)72430-4De Vries, A. (2006). Economic value of pregnancy in dairy cattle. Journal of Dairy Science, 89(10), 3876–3885. https://doi.org/10.3168/jds.s0022-0302(06)72430-4Rushton, J.(2009). The economics of animal health and production. Wallingford, UK: CABI Publishing.Rushton, J.(2009). The economics of animal health and production. Wallingford, UK: CABI Publishing.Sutarno, Setyawan, A.D. (2015). Genetic diversity of local and exotic cattle and their crossbreeding impact on the quality of Indonesian cattle. Biodiversitas, 16(2), 327–354. https://doi.org/10.13057/biodiv/d160230Sutarno, Setyawan, A.D. (2015). Genetic diversity of local and exotic cattle and their crossbreeding impact on the quality of Indonesian cattle. Biodiversitas, 16(2), 327–354. https://doi.org/10.13057/biodiv/d160230Yendraliza, Lia, Handoko, J., Harahap, A.E. (2019). Estrus Performance and Pregnancy Rate in Types of Local Cows on Different Estrus Synchronization Protocols. Animal Production, 21(2), 71–80.Yendraliza, Lia, Handoko, J., Harahap, A.E. (2019). Estrus Performance and Pregnancy Rate in Types of Local Cows on Different Estrus Synchronization Protocols. Animal Production, 21(2), 71–80.Ahmat, B., Herawati, E., Rohayati, T., Salamah, A. (2024). Differences in quantity and quality of fresh semen and frozen semen after thawing in Limousin and Simmental cattle at Lembang artificial insemination center. Jurnal Ilmu Ternak Universitas Padjadjaran, 24(1), 93–102. https://doi.org/10.24198/jit.v24i1.51460Ahmat, B., Herawati, E., Rohayati, T., Salamah, A. (2024). Differences in quantity and quality of fresh semen and frozen semen after thawing in Limousin and Simmental cattle at Lembang artificial insemination center. Jurnal Ilmu Ternak Universitas Padjadjaran, 24(1), 93–102. https://doi.org/10.24198/jit.v24i1.51460Shabirah, T. A., Suprayogi, T.W., Lestari, T. D., Hernawati, T., Rimayanti, R., Hidanah, S. (2025). Success rate of artificial insemination using sexed semen in dairy cows at the Setia Kawan dairy farmers cooperative, Pasuruan, Indonesia. Ovozoa: Journal of Animal Reproduction, 14(3), 112–118. https://doi.org/10.20473/ovz.v14i3.2025.112-118Shabirah, T. A., Suprayogi, T.W., Lestari, T. D., Hernawati, T., Rimayanti, R., Hidanah, S. (2025). Success rate of artificial insemination using sexed semen in dairy cows at the Setia Kawan dairy farmers cooperative, Pasuruan, Indonesia. Ovozoa: Journal of Animal Reproduction, 14(3), 112–118. https://doi.org/10.20473/ovz.v14i3.2025.112-118Halasa, T., Ward, M.P., Boklund, A. (2019). The impact of changing farm structure on foot-and-mouth disease spread and control: A simulation study. Transboundary and Emerging Diseases, 67(4), 1633–1644. https://doi.org/10.1111/tbed.13500Halasa, T., Ward, M.P., Boklund, A. (2019). The impact of changing farm structure on foot-and-mouth disease spread and control: A simulation study. Transboundary and Emerging Diseases, 67(4), 1633–1644. https://doi.org/10.1111/tbed.13500Butkiewicz, A.F., Amaral, A., Cerveira-Pinto, M., Kordowitzki, P. (2025). Assessing the influence of maternal age in bovine embryos and oocytes: A model for human reproductive aging. Aging and Disease, 16(2), 757–768. http://doi.org/10.14336/AD.2024.0305Butkiewicz, A.F., Amaral, A., Cerveira-Pinto, M., Kordowitzki, P. (2025). Assessing the influence of maternal age in bovine embryos and oocytes: A model for human reproductive aging. Aging and Disease, 16(2), 757–768. http://doi.org/10.14336/AD.2024.0305Ulfah. N.A., Samik, A., Hariadi, M., Suprayogi, T.W., Hidanah, S., (2022). Correlation of parity and age to services per conception, conception rate, and gestation length in Holstein Friesian cross cows. Ovozoa: Journal of Animal Reproduction, 11, 9–14. http://doi.org/10.20473/ovz.v11i1.2022.9-14Ulfah. N.A., Samik, A., Hariadi, M., Suprayogi, T.W., Hidanah, S., (2022). Correlation of parity and age to services per conception, conception rate, and gestation length in Holstein Friesian cross cows. Ovozoa: Journal of Animal Reproduction, 11, 9–14. http://doi.org/10.20473/ovz.v11i1.2022.9-14Elrashedy, A., Nayel. M., Salama, A., Zaghawa, A., El-Shabasy, R.M., Hasan, M.E. (2025). Foot-and-mouth disease: Genomic and proteomic structure, antigenic sites, serotype relationships, immune evasion, recent vaccine development strategies, and future perspectives. Veterinary Research, 56(1), Article 78. https://doi.org/10.1186/s13567-025-01485-0Elrashedy, A., Nayel. M., Salama, A., Zaghawa, A., El-Shabasy, R.M., Hasan, M.E. (2025). Foot-and-mouth disease: Genomic and proteomic structure, antigenic sites, serotype relationships, immune evasion, recent vaccine development strategies, and future perspectives. Veterinary Research, 56(1), Article 78. https://doi.org/10.1186/s13567-025-01485-0Park, J.H. (2013). Requirements for improved vaccines against foot-and-mouth disease epidemics. Clinical and Experimental Vaccine Research, 2(1), 8–18. https://doi.org/10.7774/cevr.2013.2.1.8Park, J.H. (2013). Requirements for improved vaccines against foot-and-mouth disease epidemics. Clinical and Experimental Vaccine Research, 2(1), 8–18. https://doi.org/10.7774/cevr.2013.2.1.8World Organisation for Animal Health (WOAH). (2021). Foot and mouth disease (infection with foot and mouth disease virus). Chapter in a book: Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. Paris: WOAH.World Organisation for Animal Health (WOAH). (2021). Foot and mouth disease (infection with foot and mouth disease virus). Chapter in a book: Manual of Diagnostic Tests and Vaccines for Terrestrial Animals. Paris: WOAH.Doel, T. R. (2003). FMD vaccines. Virus Research, 91(1), 81– 99. https://doi.org/10.1016/s0168-1702(02)00261-7Doel, T. R. (2003). FMD vaccines. Virus Research, 91(1), 81– 99. https://doi.org/10.1016/s0168-1702(02)00261-7Scharzenberger, S., Humphreys, J.M., Rigney, C., Freifeld, A., Stenfeldt, C., Arzt, J.(2025). Epidemiologic consequences of preclinical transmission of foot-and-mouth disease virus in cattle. Frontiers in Veterinary Science, 12(1), Article 1651091. https://doi.org/10.3389/fvets.2025.1651091Scharzenberger, S., Humphreys, J.M., Rigney, C., Freifeld, A., Stenfeldt, C., Arzt, J.(2025). Epidemiologic consequences of preclinical transmission of foot-and-mouth disease virus in cattle. Frontiers in Veterinary Science, 12(1), Article 1651091. https://doi.org/10.3389/fvets.2025.1651091Lyons, N.A., Alexander, N., Stӓrk, K.D.C., Dulu, T.D., Rushton, J., Fine, P.E.M. (2015). Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya. Veterinary Research, 46(1), Article 41. https://doi.org/10.1186/s13567-015-0173-4Lyons, N.A., Alexander, N., Stӓrk, K.D.C., Dulu, T.D., Rushton, J., Fine, P.E.M. (2015). Impact of foot-and-mouth disease on mastitis and culling on a large-scale dairy farm in Kenya. Veterinary Research, 46(1), Article 41. https://doi.org/10.1186/s13567-015-0173-4Chaters, G., Rushton, J., Dulu, T. D., Lyons, N. A. (2018). Impact of foot-and-mouth disease on fertility performance in a large dairy herd in Kenya. Preventive Veterinary Medicine, 159(1), 57–64. https://doi.org/10.1016/j.prevetmed.2018.08.006Chaters, G., Rushton, J., Dulu, T. D., Lyons, N. A. (2018). Impact of foot-and-mouth disease on fertility performance in a large dairy herd in Kenya. Preventive Veterinary Medicine, 159(1), 57–64. https://doi.org/10.1016/j.prevetmed.2018.08.006Priyanto, L., Putranti, O. D., Susanda, A., Ekowati, I. A., Abrar, A., Maemunah, S. (2025). Reproductive status of beef cows after foot and mouth disease (FMD) in East Java. BIO Web of Conferences, 162(1), Article 00009. https://doi.org/10.1051/bioconf/202516200009Priyanto, L., Putranti, O. D., Susanda, A., Ekowati, I. A., Abrar, A., Maemunah, S. (2025). Reproductive status of beef cows after foot and mouth disease (FMD) in East Java. BIO Web of Conferences, 162(1), Article 00009. https://doi.org/10.1051/bioconf/202516200009Fatmona, S., Utami, S., Gunawan. (2024). Reproduction performance as a basis for selecting female Balinese cattle in traditional breeding in East Halmahera Regency. Advances in Animal and Veterinary Sciences, 12(7), 1214–1222. https://doi.org/10.17582/journal.aavs/2024/12.7.1214.1222Fatmona, S., Utami, S., Gunawan. (2024). Reproduction performance as a basis for selecting female Balinese cattle in traditional breeding in East Halmahera Regency. Advances in Animal and Veterinary Sciences, 12(7), 1214–1222. https://doi.org/10.17582/journal.aavs/2024/12.7.1214.1222Sumiyoshi, T., Tanaka, T., Kamomae, H. (2014). Relationships between the appearances and changes of estrous signs and the estradiol-17β peak, luteinizing hormone surge, and ovulation during the periovulatory period in lactating dairy cows kept in tie-stalls. Journal of Reproduction and Development, 60(2), 106–114. https://doi.org/10.1262/jrd.2013-119Sumiyoshi, T., Tanaka, T., Kamomae, H. (2014). Relationships between the appearances and changes of estrous signs and the estradiol-17β peak, luteinizing hormone surge, and ovulation during the periovulatory period in lactating dairy cows kept in tie-stalls. Journal of Reproduction and Development, 60(2), 106–114. https://doi.org/10.1262/jrd.2013-119Riaz, U., Hassan, M., Husnain, A., Naveed, M. I., Singh, J., Ahmad, N. (2018). Effect of timing of artificial insemination in relation to onset of standing estrus on pregnancy per AI in Nili-Ravi buffalo. Animal Reproduction, 15(4), 1231–1235. https://doi.org/10.21451/1984-3143-AR2017-0015Riaz, U., Hassan, M., Husnain, A., Naveed, M. I., Singh, J., Ahmad, N. (2018). Effect of timing of artificial insemination in relation to onset of standing estrus on pregnancy per AI in Nili-Ravi buffalo. Animal Reproduction, 15(4), 1231–1235. https://doi.org/10.21451/1984-3143-AR2017-0015Ali, S., Dirre, M., Funga, A., Degefa, T., Mohammed, A., Yeshaneh, A. (2024). Behavioral and physical signs of estrous manifested in hormonally estrus-induced Boran and Holstein Friesian dairy cattle. EAS Journal of Veterinary Medical Sciences, 6(1), 1–8.Ali, S., Dirre, M., Funga, A., Degefa, T., Mohammed, A., Yeshaneh, A. (2024). Behavioral and physical signs of estrous manifested in hormonally estrus-induced Boran and Holstein Friesian dairy cattle. EAS Journal of Veterinary Medical Sciences, 6(1), 1–8.Susilo, J., Setyawan, E. M. N., Hartanto, S., Wibowo, M. H., Budiyanto, A. (2024). Effect of GnRH treatment as a potential solution for ovarian disorders in dairy cows infected with foot and mouth disease in Indonesian smallholder farms. Open Veterinary Journal, 14(8), 2079–2084. https://doi.org/10.5455/ovj.2024.v14.i8.37Susilo, J., Setyawan, E. M. N., Hartanto, S., Wibowo, M. H., Budiyanto, A. (2024). Effect of GnRH treatment as a potential solution for ovarian disorders in dairy cows infected with foot and mouth disease in Indonesian smallholder farms. Open Veterinary Journal, 14(8), 2079–2084. https://doi.org/10.5455/ovj.2024.v14.i8.37Mansur, M., Toleng, A. L., Yusuf, M., Syamsu, J.A., Hasrin, H. (2024). Critical risk factors influencing reproductive disorders in Bali cows: A comprehensive study on age, parity, and body condition score in smallholder farms of South Sulawesi. Open Veterinary Journal, 14(12), 3355–3362. https://doi.org/10.5455/OVJ.2024.v14.i12.20Mansur, M., Toleng, A. L., Yusuf, M., Syamsu, J.A., Hasrin, H. (2024). Critical risk factors influencing reproductive disorders in Bali cows: A comprehensive study on age, parity, and body condition score in smallholder farms of South Sulawesi. Open Veterinary Journal, 14(12), 3355–3362. https://doi.org/10.5455/OVJ.2024.v14.i12.20Bazot, M., Robert, Y., Mestdagh, P., Boudghène, F., Rocourt, N. (2000). Ovarian functional disorders. Journal de Radiologie, 81(12 Suppl), 1801–1818. (In French)Bazot, M., Robert, Y., Mestdagh, P., Boudghène, F., Rocourt, N. (2000). Ovarian functional disorders. Journal de Radiologie, 81(12 Suppl), 1801–1818. (In French)Butler, W. R. (2000). Nutritional interactions with reproductive performance in dairy cattle. Animal Reproduction Science, 60– 61(1), 449–457. https://doi.org/10.1016/s0378-4320(00)00076-2Butler, W. R. (2000). Nutritional interactions with reproductive performance in dairy cattle. Animal Reproduction Science, 60– 61(1), 449–457. https://doi.org/10.1016/s0378-4320(00)00076-2Salman, A., Prihatno, S. A., Sumiarto, B. (2020). Epidemiological analysis of ovarium hypofunction in beef cattle in Jepara Regency. Veterinary Practitioner, 21(2), 274–278.Salman, A., Prihatno, S. A., Sumiarto, B. (2020). Epidemiological analysis of ovarium hypofunction in beef cattle in Jepara Regency. Veterinary Practitioner, 21(2), 274–278.Bezdíček, J., Nesvadbová, A., Makarevich, A., Kubovičová, E. (2020). Relationship between the animal body condition and reproduction: The biotechnological aspects. Archives Animal Breeding, 63(1), 203–209. https://doi.org/10.5194/aab-63-203-2020Bezdíček, J., Nesvadbová, A., Makarevich, A., Kubovičová, E. (2020). Relationship between the animal body condition and reproduction: The biotechnological aspects. Archives Animal Breeding, 63(1), 203–209. https://doi.org/10.5194/aab-63-203-2020Utomo, B., Rimayanti, R., Restiadi, T. I., Amrullah, M. F. (2024). Reproductive disorders of cows in several villages of Kedamean district, Gresik regency, East Java, Indonesia in 2023. Ovozoa: Journal of Animal Reproduction, 13(1), 18–29. https://doi.org/10.20473/ovz.v13i1.2024.18-29Utomo, B., Rimayanti, R., Restiadi, T. I., Amrullah, M. F. (2024). Reproductive disorders of cows in several villages of Kedamean district, Gresik regency, East Java, Indonesia in 2023. Ovozoa: Journal of Animal Reproduction, 13(1), 18–29. https://doi.org/10.20473/ovz.v13i1.2024.18-29Hermadi, H. A., Khairullah, A. R., Damayanti, Y., Safitri, E., Tyasningsih, W., Warsito, S. H. et al. (2025). Endometritis in cattle: A review of current understanding and practical causes of repeat breeding. Trends in Sciences, 22(6), Article 9587. https://doi.org/10.48048/tis.2025.9587Hermadi, H. A., Khairullah, A. R., Damayanti, Y., Safitri, E., Tyasningsih, W., Warsito, S. H. et al. (2025). Endometritis in cattle: A review of current understanding and practical causes of repeat breeding. Trends in Sciences, 22(6), Article 9587. https://doi.org/10.48048/tis.2025.9587Gilbert, R. O., Shin, S. T., Guard, C. L., Erb, H. N., Frajblat, M. (2005). Prevalence of endometritis and its effects on reproductive performance of dairy cows. Theriogenology, 64(9), 1879– 1888. https://doi.org/10.1016/j.theriogenology.2005.04.022Gilbert, R. O., Shin, S. T., Guard, C. L., Erb, H. N., Frajblat, M. (2005). Prevalence of endometritis and its effects on reproductive performance of dairy cows. Theriogenology, 64(9), 1879– 1888. https://doi.org/10.1016/j.theriogenology.2005.04.022Faradillah, A. N., Agustina, G. C.(2023). Handlingofendometritis in dairy cow after infection with foot and mouth disease and abortion. Ovozoa: Journal of Animal Reproduction, 12(2), 107–113. https://doi.org/10.20473/ovz.v12i2.2023.107-113Faradillah, A. N., Agustina, G. C.(2023). Handlingofendometritis in dairy cow after infection with foot and mouth disease and abortion. Ovozoa: Journal of Animal Reproduction, 12(2), 107–113. https://doi.org/10.20473/ovz.v12i2.2023.107-113Stenfeldt, C., Eschbaumer, M., Humphreys, J., Medina, G.N., Arzt, J.(2025). The pathogenesis of foot-and-mouth disease virus: Current understandings and knowledge gaps. Veterinary Research, 56, Article 119. https://doi.org/10.1186/s13567025-01545-5Stenfeldt, C., Eschbaumer, M., Humphreys, J., Medina, G.N., Arzt, J.(2025). The pathogenesis of foot-and-mouth disease virus: Current understandings and knowledge gaps. Veterinary Research, 56, Article 119. https://doi.org/10.1186/s13567025-01545-5Ranjan, R., Biswal, J.K., Subramaniam, S., Singh, K. P., Stenfeldt, C., Rodriguez, L. L. et al. (2016). Foot-and-mouth disease virus-associated abortion and vertical transmission following acute infection in cattle under natural conditions. PLoS ONE, 11(12), Article e0167163. https://doi.org/10.1371/journal.pone.0167163Ranjan, R., Biswal, J.K., Subramaniam, S., Singh, K. P., Stenfeldt, C., Rodriguez, L. L. et al. (2016). Foot-and-mouth disease virus-associated abortion and vertical transmission following acute infection in cattle under natural conditions. PLoS ONE, 11(12), Article e0167163. https://doi.org/10.1371/journal.pone.0167163Alexandersen, S., Mowat, N. (2005). Foot-and-mouth disease: host range and pathogenesis. Current Topics in Microbiology and Immunology, 288(2), 9–42. https://doi.org/10.1007/3-54027109-0_2Alexandersen, S., Mowat, N. (2005). Foot-and-mouth disease: host range and pathogenesis. Current Topics in Microbiology and Immunology, 288(2), 9–42. https://doi.org/10.1007/3-54027109-0_2Hansen, P. J.(2009). Effects of heat stress on mammalian reproduction. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 364(1534), 3341–3350. https://doi.org/10.1098/rstb.2009.0131Hansen, P. J.(2009). Effects of heat stress on mammalian reproduction. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 364(1534), 3341–3350. https://doi.org/10.1098/rstb.2009.0131Deka, R. P., Magnusson, U., Grace, D., Randolph, T. F., Shome, R., Lindahl, J.F. (2021). Estimates of the economic cost caused by five major reproductive problems in dairy animals in Assam and Bihar, India. Animals, 11(11), Article 3116. https://doi.org/10.3390/ani11113116Deka, R. P., Magnusson, U., Grace, D., Randolph, T. F., Shome, R., Lindahl, J.F. (2021). Estimates of the economic cost caused by five major reproductive problems in dairy animals in Assam and Bihar, India. Animals, 11(11), Article 3116. https://doi.org/10.3390/ani11113116Constable, P., Hinchcliff, K., Done, S., Grünberg, W. (2010). Veterinary Medicine — A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats. USA, 2010.Constable, P., Hinchcliff, K., Done, S., Grünberg, W. (2010). Veterinary Medicine — A Textbook of the Diseases of Cattle, Horses, Sheep, Pigs and Goats. USA, 2010.Arend, L. S., Vinas, R. F., Silva, G. S., Lower, A. J., Connor, J.F., Knox, R. V. (2023). Effects of nursing a large litter and ovarian response to gonadotropins at weaning on subsequent fertility in first parity sows. Journal of Animal Science, 101(1), Article skac398. https://doi.org/10.1093/jas/skac398Arend, L. S., Vinas, R. F., Silva, G. S., Lower, A. J., Connor, J.F., Knox, R. V. (2023). Effects of nursing a large litter and ovarian response to gonadotropins at weaning on subsequent fertility in first parity sows. Journal of Animal Science, 101(1), Article skac398. https://doi.org/10.1093/jas/skac398

The authors declare that there are no conflicts of interest present.