meatTheory and practice of meat processingТеория и практика переработки мяса2414-438X2414-441XФГБНУ «Федеральный научный центр пищевых систем им. В.М. Горбатова» РАН10.21323/2414-438X-2025-10-2-147-155meat-461Research ArticleСтатьиThe therapeutic role of the alcoholic extract of Gundelia tourneofortti l. in Salmonella typhimurium infection and its health effects in laboratory ratsThe therapeutic role of the alcoholic extract of Gundelia tourneofortti l. in Salmonella typhimurium infection and its health effects in laboratory ratshttps://orcid.org/0000-0002-4326-5119Al-HadidyYa. I.Al-HadidyYa. I.

Yasmeen I. Al-Hadidy, hD, Associate Professor

College of Agriculture; Department of Food Sciences

34001;Tikrit

Tel.: +964–770–516–62–97

Yasmeen I. Al-Hadidy, hD, Associate Professor

College of Agriculture; Department of Food Sciences

34001;Tikrit

Tel.: +964–770–516–62–97

yasmine2017@tu.edu.iqhttps://orcid.org/0009-0001-7975-9954AbdulkreemGh. H.AbdulkreemGh. H.

Ghenaa H. Abdulkreem, PhD, Lecturer

College of Agriculture; Department of Food Sciences

34001; Tikrit

Tel.: +964–770–516–62–97

Ghenaa H. Abdulkreem, PhD, Lecturer

College of Agriculture; Department of Food Sciences

34001; Tikrit

Tel.: +964–770–516–62–97

ghnaa.hamad@tu.edu.iqhttps://orcid.org/0000-0002-6957-5289WerdiCh. M.WerdiCh. M.

Chalang M. Werdi, MSC, Assistant Lecturer

College of Veterinary Medicine; Department of Veterinary public health

36006; Taza

Tel.: +964–770–661–47–34

Chalang M. Werdi, MSC, Assistant Lecturer

College of Veterinary Medicine; Department of Veterinary public health

36006; Taza

Tel.: +964–770–661–47–34

chalangmadad@uokirkuk.edu.iqhttps://orcid.org/0000-0003-2093-9579HadiS. T.HadiS. T.

Sara T. Hadi, MSC, Associate Professor

College of Agriculture; Department of Food Sciences

Ramadi; Anbar

Tel.: +964–780–214–64–20

Sara T. Hadi, MSC, Associate Professor

College of Agriculture; Department of Food Sciences

Ramadi; Anbar

Tel.: +964–780–214–64–20

sarathamer@uoanbar.edu.iqhttps://orcid.org/0000-0001-7750-5988AltemimiA. B.AltemimiA. B.

Ammar B. Altemimi, Professor

College of Agriculture; Department of Food Science; College of Medicine

61004; Basrah; 56001; Karbala

Tel.: +964–773–564–00–90

Ammar B. Altemimi, Professor

College of Agriculture; Department of Food Science; College of Medicine

61004; Basrah; 56001; Karbala

Tel.: +964–773–564–00–90

ammar.ramddan@uobasrah.edu.iqhttps://orcid.org/0000-0002-7012-6667AbedelmaksoudT. G.AbedelmaksoudT. G.

Tarek G. Abedelmaksoud, Associate Professor

Faculty of Agriculture; Food Science Department

12613; 1 Gamaa Street; Giza

Tel.: +2–0110–144–12–80

Tarek G. Abedelmaksoud, Associate Professor

Faculty of Agriculture; Food Science Department

12613; 1 Gamaa Street; Giza

Tel.: +2–0110–144–12–80

tareekgamal_88@agr.cu.edu.egTikrit UniversityИракTikrit UniversityIraqUniversity of KirkukИракUniversity of KirkukIraqUniversity of AnbarИракUniversity of AnbarIraqUniversity of BasrahИракUniversity of Basrah; University of Warith Al-AnbiyaaIraqCairo UniversityЕгипетCairo UniversityEgypt202506072025102147155Copyright © Al-Hadidy Y.I., Abdulkreem G.H., Werdi C.M., Hadi S.T., Altemimi A.B., Abedelmaksoud T.G., 20252025Al-Hadidy Y.I., Abdulkreem G.H., Werdi C.M., Hadi S.T., Altemimi A.B., Abedelmaksoud T.G.Al-Hadidy Y.I., Abdulkreem G.H., Werdi C.M., Hadi S.T., Altemimi A.B., Abedelmaksoud T.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.meatjournal.ru/jour/article/view/461

   This study investigates the effectiveness of the alcoholic extract of Gundelia tournefortii L. in mitigating the effects of Salmonella Typhimurium infection on hematological parameters and liver and kidney function in laboratory animals. S. Typhimurium was isolated from 23 samples of food and stool collected from pediatric patients (aged 1–6 years) with diarrhea at Salah al-Din Hospital. The findings indicate that infection with S. Typhimurium led to a significant increase (P < 0.05) in total white blood cell (WBC) and platelet counts, reaching 28.16 × 10³/µL and 713 × 10³/µL, respectively, compared to the control values of 8.50 × 10³/µL and 658 × 10³/µL. Conversely, red blood cell (RBC) and hemoglobin (Hb) levels were significantly reduced (P < 0.05) in infected animals, measuring 5.79 × 10⁶/µL and 13.0 g/dL, respectively, compared to 4.60 × 10⁶/µL and 14.10 g/dL in the control group. Liver function tests revealed elevated levels of alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in infected rats, with values of 164.0, 142.0, and 66.0 IU/L, respectively, compared to the control values. Renal function analysis showed a significant increase (P < 0.05) in urea concentration in the infected group (48.5 mg/dL) relative to the controls (41.2 mg/dL), while no significant differences were observed in creatinine levels between groups. Notably, administration of the alcoholic extract at doses of 200 and 400 µg/kg significantly mitigated the adverse effects of infection, demonstrating its potential therapeutic efficacy.

   This study investigates the effectiveness of the alcoholic extract of Gundelia tournefortii L. in mitigating the effects of Salmonella Typhimurium infection on hematological parameters and liver and kidney function in laboratory animals. S. Typhimurium was isolated from 23 samples of food and stool collected from pediatric patients (aged 1–6 years) with diarrhea at Salah al-Din Hospital. The findings indicate that infection with S. Typhimurium led to a significant increase (P < 0.05) in total white blood cell (WBC) and platelet counts, reaching 28.16 × 10³/µL and 713 × 10³/µL, respectively, compared to the control values of 8.50 × 10³/µL and 658 × 10³/µL. Conversely, red blood cell (RBC) and hemoglobin (Hb) levels were significantly reduced (P < 0.05) in infected animals, measuring 5.79 × 10⁶/µL and 13.0 g/dL, respectively, compared to 4.60 × 10⁶/µL and 14.10 g/dL in the control group. Liver function tests revealed elevated levels of alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in infected rats, with values of 164.0, 142.0, and 66.0 IU/L, respectively, compared to the control values. Renal function analysis showed a significant increase (P < 0.05) in urea concentration in the infected group (48.5 mg/dL) relative to the controls (41.2 mg/dL), while no significant differences were observed in creatinine levels between groups. Notably, administration of the alcoholic extract at doses of 200 and 400 µg/kg significantly mitigated the adverse effects of infection, demonstrating its potential therapeutic efficacy.

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The authors declare that there are no conflicts of interest present.