meatTheory and practice of meat processingТеория и практика переработки мяса2414-438X2414-441XФГБНУ «Федеральный научный центр пищевых систем им. В.М. Горбатова» РАН10.21323/2414-438X-2022-7-3-193-199meat-229Research ArticleСтатьиContribution of some immunological and metabolic factors to formation of piglets’ post-vaccination immunityContribution of some immunological and metabolic factors to formation of piglets’ post-vaccination immunityhttps://orcid.org/0000-0003-3818-0556DerkhoM. A.DerkhoM. A.

Marina A. Derkho, Doctor of Biological Sciences, Professor, Institute of Veterinary Medicine

13, Gagarin str., Troitsk, 457103

Tel.: +7–351–632–00–10

kaf.himec@sursau.ruhttps://orcid.org/0000-0001-7515-5670BurkovP. V.BurkovP. V.

Pavel V. Burkov, Candidate of Veterinary Sciences, Docent, Institute of Veterinary Medicine

3, Gagarin str., Troitsk, 457103

Tel.: +7–351–632–00–10

burkovpv@sursau.ruhttps://orcid.org/0000-0001-8685-4645ScherbakovP. N.ShcherbakovP. N.

Pavel N. Shcherbakov, Doctor of Veterinary Sciences, Docent, Institute of Veterinary Medicine

3, Gagarin str., Troitsk, 457103

Tel.: +7–351–632–00–10

scherbakov_pavel@mail.ruhttps://orcid.org/0000-0003-0857-5143RebezovM. B.RebezovM. B.

Maksim B. Rebezov, Doctor of Agricultural Sciences, Candidate of Veterinary Sciences, Professor, Leading Researcher

26, Talalikhin str., 109316, Moscow

Tel.: +7–999–900–23–65

rebezov@yandex.ruhttps://orcid.org/0000-0002-3916-004XStepanovaK. V.StepanovaK. V.

Ksenia V. Stepanova, Candidate of Biological Sciences, Docent, Institute of Veterinary Medicine

13, Gagarin str., Troitsk, 457103

Tel.: +7–351–632–00–10

deratizator@bk.ruhttps://orcid.org/0000-0002-1279-3904AnsoriA.N M.AnsoriA. N. M.

Arif N. M. Ansori, Doctor in Veterinary Science, Faculty of Veterinary Medicine

Jl. Mulyorejo, Kec. Mulyorejo, Surabaya, East Java, 60115

South Ural State Agrarian UniversityRussian FederationV.M. Gorbatov Federal Scientific Center of Food SystemsRussian FederationUniversitas AirlanggaIndonesia20221410202273193199Copyright © Derkho M.A., Burkov P.V., Shcherbakov P.N., Rebezov M.B., Stepanova K.V., Ansori A.M., 20222022Derkho M.A., Burkov P.V., Scherbakov P.N., Rebezov M.B., Stepanova K.V., Ansori A.M.Derkho M.A., Burkov P.V., Shcherbakov P.N., Rebezov M.B., Stepanova K.V., Ansori A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.meatjournal.ru/jour/article/view/229

The role and responsibility of natural resistance factors, protein and lipid metabolism in the formation of piglets post-vaccination immunity against circovirus is researched. Blood was taken for tests before and on the 15th, 40th and 70th day after the vaccination. The sampled blood was analyzed to determine immunological and biochemical parameters. It was revealed that before vaccination, 31.46% of the studied samples have a positive reaction in ELISA; their number increases to 67.80–71.16% on the 40th and 70th days after vaccination.In the blood of piglets, especially on the 40th and 70th day after the vaccination, the total count of leukocytes, monocytes and lymphocytes increases by 1.21; 2.28 times and 1.48 times, but neutrophils reduced by 1.74 times along with the phagocytic properties activation. The anabolic directivity of protein metabolism is defined by the synthesis of globulin proteins. At the same time albumin-synthesizing activity in a liver decreased and “cytolysis reaction” of hepatocytes was detected. In the lipid profile of piglets’ blood, the content of LDL‑cholesterol increased by 1.44 times, while that of triglycerides decreased by 2.64 times. X‑ray spectral analysis revealed the correlation between the formation of post-vaccination immunity and two factors: the factor of the principal component (PC) 1, which is predominantly associated with indicators of natural resistance, and PC2, which is associated with metabolism indicators. The research results show that in order to increase the efficiency of formation of post-vaccination immunity in piglets, it is necessary to combine vaccination with hepatoprotective drugs.

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The authors declare that there are no conflicts of interest present.